| 9/4/2010 | Macalester Scots 35 @ Grinnell 45 | |
| 9/11/2010 | Grinnell 17 @ Monmouth IL Scots 15 | † |
| 9/18/2010 | Ripon Red Hawks 48 @ Grinnell 21 | † |
| 9/25/2010 | Grinnell 41 @ Lake Forest Foresters 20 | † |
| 10/2/2010 | Beloit Buccaneers 21 @ Grinnell 24 | † |
| 10/9/2010 | Grinnell 21 @ Knox Prairie Fire 31 | † |
| 10/16/2010 | Lawrence Vikings 17 @ Grinnell 31 | † |
| 10/23/2010 | Grinnell 14 @ St Norbert Green Knights 58 | † |
| 10/30/2010 | Illinois College Blue Boys 29 @ Grinnell 42 | † |
| 11/6/2010 | Grinnell 7 @ Carroll WI Pioneers 40 | † |