| 9/4/2010 | Knox 3 @ Washington U Bears 34 | |
| 9/11/2010 | Knox 12 @ Lawrence Vikings 33 | † |
| 9/18/2010 | St Norbert Green Knights 49 @ Knox 0 | † |
| 9/25/2010 | Knox 7 @ Beloit Buccaneers 42 | † |
| 10/2/2010 | Ripon Red Hawks 56 @ Knox 14 | † |
| 10/9/2010 | Grinnell Pioneers 21 @ Knox 31 | † |
| 10/16/2010 | Knox 23 @ Illinois College Blue Boys 31 | † |
| 10/23/2010 | Carroll WI Pioneers 35 @ Knox 0 | † |
| 10/30/2010 | Knox 6 @ Lake Forest Foresters 35 | † |
| 11/6/2010 | Monmouth IL Scots 42 @ Knox 6 | † |