| 9/4/2010 | Millikin Big Blue 42 @ Illinois College 31 | |
| 9/11/2010 | Illinois College 20 @ Carroll WI Pioneers 34 | † |
| 9/18/2010 | Lake Forest Foresters 7 @ Illinois College 27 | † |
| 9/25/2010 | Illinois College 9 @ Monmouth IL Scots 33 | † |
| 10/2/2010 | Lawrence Vikings 21 @ Illinois College 45 | † |
| 10/9/2010 | Illinois College 26 @ St Norbert Green Knights 25 | † |
| 10/16/2010 | Knox Prairie Fire 23 @ Illinois College 31 | † |
| 10/23/2010 | Ripon Red Hawks 35 @ Illinois College 40 | † |
| 10/30/2010 | Illinois College 29 @ Grinnell Pioneers 42 | † |
| 11/6/2010 | Illinois College 27 @ Beloit Buccaneers 42 | † |