| 9/4/2010 | Concordia IL Cougars 52 @ Lake Forest 23 | |
| 9/11/2010 | Lake Forest 19 @ Ripon Red Hawks 64 | † |
| 9/18/2010 | Lake Forest 7 @ Illinois College Blue Boys 27 | † |
| 9/25/2010 | Grinnell Pioneers 41 @ Lake Forest 20 | † |
| 10/2/2010 | Lake Forest 7 @ Carroll WI Pioneers 15 | † |
| 10/9/2010 | Beloit Buccaneers 33 @ Lake Forest 27 1OT | † |
| 10/16/2010 | Lake Forest 10 @ Monmouth IL Scots 27 | † |
| 10/23/2010 | Lawrence Vikings 14 @ Lake Forest 35 | † |
| 10/30/2010 | Knox Prairie Fire 6 @ Lake Forest 35 | † |
| 11/6/2010 | Lake Forest 0 @ St Norbert Green Knights 28 | † |