| 8/28/2010 | Morehouse 34 @ Benedict Tigers 27 | † |
| 9/4/2010 | Morehouse 47 @ Fort Valley State Wildcats 34 | † |
| 9/11/2010 | Lane Dragons 6 @ Morehouse 49 | † |
| 9/18/2010 | Kentucky State Thorobreds 25 @ Morehouse 41 | † |
| 9/25/2010 | Lincoln MO Blue Tigers 14 @ Morehouse 30 | |
| 10/9/2010 | Morehouse 15 vs Tuskegee Golden Tigers 31 (Columbus GA) | † |
| 10/16/2010 | Morehouse 38 @ Stillman Tigers 24 | † |
| 10/23/2010 | Albany State GA Golden Rams 13 @ Morehouse 12 | † |
| 10/30/2010 | Morehouse 17 @ Clark Atlanta Panthers 7 | † |
| 11/6/2010 | Morehouse 13 @ Miles Golden Bears 3 | † |
| 11/20/2010 | Morehouse 41 @ Wingate Bulldogs 63 |