| 9/5/2010 | Delaware St | vs | Southern Univ | ||||||
| 9/11/2010 | Arkansas-Monticello D2 | @ | Southern Univ | ||||||
| 9/25/2010 | Southern Univ | @ | Alabama A&M | SWAC | |||||
| 10/2/2010 | Ark Pine Bluff | @ | Southern Univ | SWAC | |||||
| 10/9/2010 | MS Valley St | @ | Southern Univ | SWAC | |||||
| 10/16/2010 | Southern Univ | @ | Jackson St | SWAC | |||||
| 10/23/2010 | Prairie View | vs | Southern Univ | SWAC | |||||
| 10/30/2010 | Southern Univ | @ | Alcorn St | SWAC | |||||
| 11/6/2010 | Texas Southern | @ | Southern Univ | SWAC | |||||
| 11/13/2010 | Alabama St | @ | Southern Univ | SWAC | |||||
| 11/27/2010 | Grambling | vs | Southern Univ | SWAC |