| 9/5/2010 | Delaware St | vs | Southern Univ | ||||||
| 9/11/2010 | Florida A&M | @ | Delaware St | MEAC | |||||
| 9/25/2010 | Delaware St | @ | Coastal Car | ||||||
| 10/2/2010 | Hampton | @ | Delaware St | MEAC | |||||
| 10/9/2010 | Delaware St | @ | Bethune-Cookman | MEAC | |||||
| 10/16/2010 | NC A&T | @ | Delaware St | MEAC | |||||
| 10/23/2010 | Delaware St | @ | Morgan St | MEAC | |||||
| 10/30/2010 | S Carolina St | @ | Delaware St | MEAC | |||||
| 11/6/2010 | North Carolina Central | @ | Delaware St | ||||||
| 11/13/2010 | Delaware St | @ | Norfolk St | MEAC | |||||
| 11/20/2010 | Delaware St | @ | Howard | MEAC |