| 9/4/2010 | MS Valley St | @ | Alabama St | SWAC | |||||
| 9/11/2010 | MS Valley St | @ | S Carolina St | ||||||
| 9/18/2010 | Alcorn St | @ | MS Valley St | SWAC | |||||
| 9/25/2010 | MS Valley St | @ | Jackson St | SWAC | |||||
| 10/2/2010 | Prairie View | @ | MS Valley St | SWAC | |||||
| 10/9/2010 | MS Valley St | @ | Southern Univ | SWAC | |||||
| 10/23/2010 | Grambling | @ | MS Valley St | SWAC | |||||
| 10/30/2010 | MS Valley St | @ | Texas Southern | SWAC | |||||
| 11/6/2010 | MS Valley St | @ | Ark Pine Bluff | SWAC | |||||
| 11/13/2010 | Alabama A&M | @ | MS Valley St | SWAC |