| 9/4/2010 | Delta St D2 | @ | Jackson St | ||||||
| 9/11/2010 | Jackson St | vs | Tennessee St | ||||||
| 9/18/2010 | Jackson St | @ | Grambling | SWAC | |||||
| 9/25/2010 | MS Valley St | @ | Jackson St | SWAC | |||||
| 10/9/2010 | Alabama A&M | @ | Jackson St | SWAC | |||||
| 10/16/2010 | Southern Univ | @ | Jackson St | SWAC | |||||
| 10/23/2010 | Jackson St | @ | Texas Southern | SWAC | |||||
| 10/30/2010 | Prairie View | @ | Jackson St | SWAC | |||||
| 11/6/2010 | Jackson St | @ | Alabama St | SWAC | |||||
| 11/13/2010 | Jackson St | @ | Ark Pine Bluff | SWAC | |||||
| 11/20/2010 | Alcorn St | @ | Jackson St | SWAC |