| 9/4/2010 | MS Valley St | @ | Alabama St | SWAC | |||||
| 9/11/2010 | Ark Pine Bluff | @ | Alabama St | SWAC | |||||
| 9/18/2010 | Alabama St | @ | Prairie View | SWAC | |||||
| 9/25/2010 | Alabama St | @ | Alcorn St | SWAC | |||||
| 10/2/2010 | Texas Southern | @ | Alabama St | SWAC | |||||
| 10/9/2010 | Alabama St | @ | Grambling | SWAC | |||||
| 10/23/2010 | Savannah St | @ | Alabama St | ||||||
| 10/30/2010 | Alabama A&M | vs | Alabama St | SWAC | |||||
| 11/6/2010 | Jackson St | @ | Alabama St | SWAC | |||||
| 11/13/2010 | Alabama St | @ | Southern Univ | SWAC | |||||
| 11/25/2010 | Tuskegee D2 | @ | Alabama St |