| 9/4/2010 | Alabama A&M | @ | Tennessee St | ||||||
| 9/11/2010 | Jackson St | vs | Tennessee St | ||||||
| 9/18/2010 | Austin Peay | @ | Tennessee St | OVC | |||||
| 9/25/2010 | Florida A&M | vs | Tennessee St | ||||||
| 10/2/2010 | NC A&T | vs | Tennessee St | ||||||
| 10/9/2010 | Tennessee St | @ | SE Missouri St | OVC | |||||
| 10/16/2010 | Tennessee St | @ | Jacksonville St | OVC | |||||
| 10/23/2010 | Tennessee Tech | @ | Tennessee St | OVC | |||||
| 11/6/2010 | Eastern Illinois | @ | Tennessee St | OVC | |||||
| 11/13/2010 | Tennessee St | @ | Tennessee-Martin | OVC | |||||
| 11/20/2010 | Tennessee St | @ | Murray St | OVC |