| 8/27/2009 | Quincy 26 @ Indiana St 20 1OT | |
| 9/5/2009 | Indiana St 10 @ Louisville 30 | |
| 9/12/2009 | Eastern Illinois 31 @ Indiana St 0 | |
| 9/19/2009 | Indiana St 0 @ S Dakota St 41 | † |
| 9/26/2009 | Youngstown St 28 @ Indiana St 0 | † |
| 10/3/2009 | Indiana St 7 @ Northern Iowa 62 | † |
| 10/17/2009 | Indiana St 21 @ Illinois St 38 | † |
| 10/24/2009 | Western Illinois 14 @ Indiana St 17 | † |
| 10/31/2009 | Southern Illinois 33 @ Indiana St 0 | † |
| 11/7/2009 | Indiana St 7 @ Missouri State 31 | † |
| 11/14/2009 | N Dakota St 56 @ Indiana St 17 | † |