| 9/5/2009 | Prairie View 17 @ Texas Southern 7 | † |
| 9/12/2009 | Prairie View 18 @ New Mexico St 21 | |
| 10/3/2009 | Grambling 32 vs Prairie View 35 (Dallas TX) | † |
| 10/10/2009 | Prairie View 24 @ Alabama St 10 | † |
| 10/17/2009 | MS Valley St 0 @ Prairie View 38 | † |
| 10/22/2009 | Prairie View 16 @ Southern Univ 14 | † |
| 11/7/2009 | Alabama A&M 27 @ Prairie View 33 | † |
| 11/14/2009 | Prairie View 34 @ Alcorn St 14 | † |
| 11/21/2009 | Ark Pine Bluff 17 @ Prairie View 49 | † |
| 12/12/2009 | Alabama A&M 24 vs Prairie View 30 | † |