| 9/5/2009 | Southern Univ 19 @ UL Lafayette 42 | |
| 9/12/2009 | Central St 0 @ Southern Univ 68 | |
| 9/19/2009 | Tennessee St 17 @ Southern Univ 21 | |
| 9/26/2009 | Alcorn St 42 @ Southern Univ 48 | † |
| 10/3/2009 | Southern Univ 14 @ Jackson St 22 | † |
| 10/17/2009 | Fort Valley St 23 @ Southern Univ 55 | |
| 10/22/2009 | Prairie View 16 @ Southern Univ 14 | † |
| 10/31/2009 | Southern Univ 24 @ Ark Pine Bluff 10 | † |
| 11/14/2009 | Alabama St 24 vs Southern Univ 34 (Mobile AL) | † |
| 11/28/2009 | Southern Univ 13 vs Grambling 31 (New Orleans LA) | † |
| 12/5/2009 | Southern Univ 25 @ Texas Southern 30 | † |