| 9/5/2009 | MS Valley St 0 @ Arkansas St 61 | |
| 9/19/2009 | Ark Pine Bluff 27 @ MS Valley St 7 | † |
| 9/26/2009 | Alabama St 3 vs MS Valley St 10 (Chicago IL) | † |
| 10/3/2009 | Texas College 6 @ MS Valley St 61 | |
| 10/10/2009 | MS Valley St 10 @ Alcorn St 32 | † |
| 10/17/2009 | MS Valley St 0 @ Prairie View 38 | † |
| 10/24/2009 | Jackson St 25 @ MS Valley St 16 | † |
| 10/31/2009 | MS Valley St 7 @ Grambling 50 | † |
| 11/7/2009 | Texas Southern 30 @ MS Valley St 7 | † |
| 11/14/2009 | Lincoln MO 6 @ MS Valley St 16 | |
| 11/21/2009 | MS Valley St 12 @ Alabama A&M 17 | † |