| 9/3/2005 | #5 Notre Dame | 42 | @ | Pittsburgh | 21 | ||||
| 9/9/2005 | Pittsburgh | 10 | @ | Ohio | 16 | OT | |||
| 9/17/2005 | Pittsburgh | 6 | @ | Nebraska | 7 | ||||
| 9/24/2005 | Youngstown St | 0 | @ | Pittsburgh | 41 | ||||
| 9/30/2005 | Pittsburgh | 29 | @ | Rutgers | 37 | BigE | |||
| 10/8/2005 | Cincinnati | 20 | @ | Pittsburgh | 38 | BigE | |||
| 10/15/2005 | South Florida | 17 | @ | Pittsburgh | 31 | BigE | |||
| 10/22/2005 | Syracuse | 17 | @ | Pittsburgh | 34 | BigE | |||
| 11/3/2005 | Pittsburgh | 20 | @ | #15 Louisville | 42 | BigE | |||
| 11/12/2005 | Connecticut | 0 | @ | Pittsburgh | 24 | BigE | |||
| 11/24/2005 | Pittsburgh | 13 | @ | #11 West Virginia | 45 | BigE |