| 9/3/2022 | Chicago | 34 | at | Concordia IL (3-7) | 14 | at NAC | ||
| 9/10/2022 | Chicago | 40 | at | Illinois College (5-4,4-4) | 14 | |||
| 9/17/2022 | Beloit (1-9,1-8) | 10 | at | Chicago | 43 | |||
| 10/1/2022 | Chicago | 50 | at | Knox (5-5,4-5) | 14 | |||
| 10/8/2022 | Monmouth IL (9-2,8-1) | 23 | at | Chicago | 20 | |||
| 10/15/2022 | Cornell IA (3-7,3-6) | 7 | at | Chicago | 45 | |||
| 10/22/2022 | Chicago | 16 | at | Ripon (9-1,8-1) | 19 | |||
| 10/29/2022 | Grinnell (2-6,2-6) | 0 | at | Chicago | 58 | |||
| 11/5/2022 | Chicago | 60 | at | Lawrence (0-10,0-9) | 0 | |||
| 11/12/2022 | Lake Forest (9-2,8-1) | 13 | at | Chicago | 7 |
| vs Chicago | vs Other Opponents | Chicago compared to OOs | |
| Record: | 3-7 | 43-46 | |
| Points Scored: | 11.40 | 25.09 | 13.69 |
| Points Allowed: | 37.30 | 27.27 | 10.03 |
| Margin: | -25.90 | -2.18 | 23.72 |
| Total Points: | 48.70 | 52.36 | -3.66 |