| 9/1/2022 | Illinois College | 38 | at | Lakeland (3-7) | 20 | at NAC | ||
| 9/10/2022 | Chicago (7-3,6-3) | 40 | at | Illinois College | 14 | |||
| 9/17/2022 | Illinois College | 20 | at | Monmouth IL (9-2,8-1) | 51 | |||
| 10/1/2022 | Ripon (9-1,8-1) | 23 | at | Illinois College | 21 | |||
| 10/8/2022 | Illinois College | 7 | at | Lake Forest (9-2,8-1) | 40 | |||
| 10/15/2022 | Lawrence (0-10,0-9) | 0 | at | Illinois College | 57 | |||
| 10/22/2022 | Illinois College | 20 | at | Knox (5-5,4-5) | 10 | |||
| 10/28/2022 | Cornell IA (3-7,3-6) | 14 | at | Illinois College | 28 | |||
| 11/5/2022 | Illinois College | at | Grinnell (2-6,2-6) | PPD | ||||
| 11/12/2022 | Beloit (1-9,1-8) | 13 | at | Illinois College | 65 |
| vs Illinois College | vs Other Opponents | Illinois College compared to OOs | |
| Record: | 4-5 | 44-47 | |
| Points Scored: | 23.44 | 25.41 | 1.97 |
| Points Allowed: | 30.00 | 26.69 | 3.31 |
| Margin: | -6.56 | -1.28 | 5.28 |
| Total Points: | 53.44 | 52.10 | 1.34 |