| 8/28/2021 | Evangel (5-6,5-6) | 24 | at | Clarke | 9 | |||
| 9/4/2021 | Clarke | 20 | at | Missouri Valley (3-8,3-8) | 44 | |||
| 9/11/2021 | Central Methodist (9-3,9-2) | 31 | at | Clarke | 16 | |||
| 9/18/2021 | Clarke | 0 | at | Benedictine KS (7-4,7-4) | 68 | |||
| 9/25/2021 | Baker (9-2,9-2) | 41 | at | Clarke | 6 | |||
| 10/2/2021 | Clarke | 39 | at | MidAmerica Nazarene (3-8,3-8) | 56 | |||
| 10/16/2021 | Clarke | 0 | at | Peru State (7-4,7-4) | 20 | |||
| 10/23/2021 | Culver-Stockton (8-3,8-3) | 17 | at | Clarke | 6 | |||
| 10/30/2021 | Clarke | 37 | at | Graceland (0-11,0-11) | 14 | |||
| 11/6/2021 | William Penn (3-8,3-8) | 28 | at | Clarke | 17 | |||
| 11/13/2021 | Grand View (14-1,11-0) | 31 | at | Clarke | 7 |
| vs Clarke | vs Other Opponents | Clarke compared to OOs | |
| Record: | 10-1 | 58-57 | |
| Points Scored: | 34.00 | 29.03 | -4.97 |
| Points Allowed: | 14.27 | 28.87 | -14.60 |
| Margin: | 19.73 | 0.16 | -19.57 |
| Total Points: | 48.27 | 57.90 | -9.63 |