| 8/28/2021 | Central Methodist (9-3,9-2) | 10 | at | Grand View | 37 | | | |
| 9/4/2021 | Grand View | 41 | at | Benedictine KS (7-4,7-4) | 20 | | | |
| 9/11/2021 | Baker (9-2,9-2) | 14 | at | Grand View | 31 | | | |
| 9/18/2021 | Grand View | 47 | at | MidAmerica Nazarene (3-8,3-8) | 21 | | | |
| 9/25/2021 | Evangel (5-6,5-6) | 6 | at | Grand View | 23 | | | |
| 10/2/2021 | Grand View | 59 | at | Missouri Valley (3-8,3-8) | 10 | | | |
| 10/16/2021 | William Penn (3-8,3-8) | 0 | at | Grand View | 38 | | | |
| 10/23/2021 | Grand View | 77 | at | Graceland (0-11,0-11) | 9 | | | |
| 10/30/2021 | Peru State (7-4,7-4) | 7 | at | Grand View | 27 | | | |
| 11/6/2021 | Culver-Stockton (8-3,8-3) | 6 | at | Grand View | 9 | | | |
| 11/13/2021 | Grand View | 31 | at | Clarke (1-10,1-10) | 7 | | | |
| 11/20/2021 | Dickinson State (8-3) | 13 | at | Grand View | 38 | | | NSAA |
| 11/27/2021 | Concordia MI (9-2) | 16 | at | Grand View | 31 | | | MSFA |
| 12/4/2021 | Grand View | 34 | at | Lindsey Wilson (12-1) | 28 | | | at MSC |
| 12/18/2021 | Grand View | 28 | vs | Morningside (14-0) | 38 | | NAIA Championship - Durham NC | vs GPAC |