| 8/28/2021 | Missouri Valley (3-8,3-8) | 21 | at | Peru State | 47 | | | |
| 9/4/2021 | Peru State | 24 | at | Central Methodist (9-3,9-2) | 27 | | | |
| 9/11/2021 | Benedictine KS (7-4,7-4) | 21 | at | Peru State | 45 | | | |
| 9/18/2021 | Peru State | 3 | at | Baker (9-2,9-2) | 33 | | | |
| 9/25/2021 | MidAmerica Nazarene (3-8,3-8) | 14 | at | Peru State | 21 | | | |
| 10/2/2021 | Peru State | 23 | at | Evangel (5-6,5-6) | 22 | | | |
| 10/16/2021 | Clarke (1-10,1-10) | 0 | at | Peru State | 20 | | | |
| 10/23/2021 | Peru State | 28 | at | William Penn (3-8,3-8) | 0 | | | |
| 10/30/2021 | Peru State | 7 | at | Grand View (14-1,11-0) | 27 | | | |
| 11/6/2021 | Graceland (0-11,0-11) | 7 | at | Peru State | 51 | | | |
| 11/13/2021 | Peru State | 3 | at | Culver-Stockton (8-3,8-3) | 10 | | | |