| 8/28/2021 | MidAmerica Nazarene (3-8,3-8) | 49 | at | Graceland | 17 | | | |
| 9/4/2021 | Graceland | 0 | at | Evangel (5-6,5-6) | 62 | | | |
| 9/11/2021 | Missouri Valley (3-8,3-8) | 38 | at | Graceland | 24 | | | |
| 9/18/2021 | Graceland | 0 | at | Central Methodist (9-3,9-2) | 44 | | | |
| 9/25/2021 | Benedictine KS (7-4,7-4) | 62 | at | Graceland | 7 | | | |
| 10/2/2021 | Graceland | 7 | at | Baker (9-2,9-2) | 58 | | | |
| 10/16/2021 | Culver-Stockton (8-3,8-3) | 50 | at | Graceland | 3 | | | |
| 10/23/2021 | Grand View (14-1,11-0) | 77 | at | Graceland | 9 | | | |
| 10/30/2021 | Clarke (1-10,1-10) | 37 | at | Graceland | 14 | | | |
| 11/6/2021 | Graceland | 7 | at | Peru State (7-4,7-4) | 51 | | | |
| 11/13/2021 | Graceland | 6 | at | William Penn (3-8,3-8) | 71 | | | |