| 8/28/2021 | Missouri Valley | 21 | at | Peru State (7-4,7-4) | 47 | | | |
| 9/4/2021 | Clarke (1-10,1-10) | 20 | at | Missouri Valley | 44 | | | |
| 9/11/2021 | Missouri Valley | 38 | at | Graceland (0-11,0-11) | 24 | | | |
| 9/18/2021 | Culver-Stockton (8-3,8-3) | 52 | at | Missouri Valley | 28 | | | |
| 9/25/2021 | Missouri Valley | 30 | at | William Penn (3-8,3-8) | 27 | | | |
| 10/2/2021 | Grand View (14-1,11-0) | 59 | at | Missouri Valley | 10 | | | |
| 10/16/2021 | Evangel (5-6,5-6) | 30 | at | Missouri Valley | 23 | | | |
| 10/23/2021 | Missouri Valley | 37 | at | Benedictine KS (7-4,7-4) | 47 | | | |
| 10/30/2021 | Missouri Valley | 7 | at | Central Methodist (9-3,9-2) | 41 | | | |
| 11/6/2021 | MidAmerica Nazarene (3-8,3-8) | 42 | at | Missouri Valley | 35 | OT | | |
| 11/13/2021 | Baker (9-2,9-2) | 45 | at | Missouri Valley | 14 | | | |