| 8/28/2021 | Briar Cliff | 3 | at | Waldorf (7-3) | 30 | at NSAA | ||
| 9/4/2021 | Doane (5-5,5-5) | 17 | at | Briar Cliff | 3 | |||
| 9/11/2021 | Briar Cliff | 21 | at | Concordia NE (7-3,7-3) | 61 | |||
| 9/25/2021 | Briar Cliff | 36 | at | Mount Marty (0-10,0-10) | 28 | |||
| 10/2/2021 | Hastings (2-8,2-8) | 24 | at | Briar Cliff | 23 | |||
| 10/9/2021 | Briar Cliff | 7 | at | Midland U. (6-5,6-4) | 59 | |||
| 10/16/2021 | Morningside (14-0,11-0) | 84 | at | Briar Cliff | 7 | |||
| 10/23/2021 | Briar Cliff | 41 | at | Jamestown (2-9,2-8) | 38 | |||
| 10/30/2021 | Dakota Wesleyan (4-7,4-6) | 14 | at | Briar Cliff | 20 | |||
| 11/6/2021 | Briar Cliff | 0 | at | Dordt (7-3,7-3) | 58 | |||
| 11/13/2021 | Northwestern IA (12-2,9-2) | 63 | at | Briar Cliff | 7 |
| vs Briar Cliff | vs Other Opponents | Briar Cliff compared to OOs | |
| Record: | 8-3 | 58-52 | |
| Points Scored: | 43.27 | 27.59 | -15.68 |
| Points Allowed: | 15.27 | 26.23 | -10.96 |
| Margin: | 28.00 | 1.36 | -26.64 |
| Total Points: | 58.54 | 53.82 | 4.72 |