| 9/4/2021 | St Mary KS | 10 | at | Sterling (6-6,5-5) | 49 | |||
| 9/18/2021 | St Mary KS | 0 | at | Southwestern (9-2,9-1) | 44 | |||
| 9/25/2021 | Friends (1-9,1-9) | 7 | at | St Mary KS | 55 | |||
| 10/2/2021 | St Mary KS | 7 | at | Kansas Wesleyan (10-2,9-1) | 49 | |||
| 10/9/2021 | Ottawa (5-6,4-6) | 37 | at | St Mary KS | 14 | |||
| 10/16/2021 | St Mary KS | 38 | at | Bethany KS (0-10,0-10) | 6 | |||
| 10/23/2021 | Avila (7-3,7-3) | 39 | at | St Mary KS | 31 | |||
| 10/30/2021 | McPherson (6-4,6-4) | 28 | at | St Mary KS | 26 | |||
| 11/6/2021 | Bethel KS (9-2,9-1) | 54 | at | St Mary KS | 21 | |||
| 11/13/2021 | St Mary KS | 14 | at | Tabor (3-8,2-8) | 7 |
| vs St Mary KS | vs Other Opponents | St Mary KS compared to OOs | |
| Record: | 7-3 | 49-49 | |
| Points Scored: | 32.00 | 29.27 | -2.73 |
| Points Allowed: | 21.60 | 29.00 | -7.40 |
| Margin: | 10.40 | 0.27 | -10.13 |
| Total Points: | 53.60 | 58.27 | -4.67 |