| 8/28/2021 | Ottawa | 42 | at | Panhandle State (4-7) | 7 | at Soon | ||
| 9/4/2021 | Ottawa | 13 | at | Southwestern (9-2,9-1) | 41 | |||
| 9/11/2021 | Avila (7-3,7-3) | 38 | at | Ottawa | 14 | |||
| 9/18/2021 | Ottawa | 14 | at | McPherson (6-4,6-4) | 33 | |||
| 9/25/2021 | Bethel KS (9-2,9-1) | 40 | at | Ottawa | 17 | |||
| 10/2/2021 | Tabor (3-8,2-8) | 22 | at | Ottawa | 45 | |||
| 10/9/2021 | Ottawa | 37 | at | St Mary KS (3-7,3-7) | 14 | |||
| 10/23/2021 | Friends (1-9,1-9) | 14 | at | Ottawa | 28 | |||
| 10/30/2021 | Ottawa | 21 | at | Kansas Wesleyan (10-2,9-1) | 35 | |||
| 11/6/2021 | Ottawa | 6 | at | Sterling (6-6,5-5) | 21 | |||
| 11/13/2021 | Bethany KS (0-10,0-10) | 17 | at | Ottawa | 55 |
| vs Ottawa | vs Other Opponents | Ottawa compared to OOs | |
| Record: | 6-5 | 52-55 | |
| Points Scored: | 25.64 | 29.44 | 3.80 |
| Points Allowed: | 26.55 | 29.21 | -2.66 |
| Margin: | -0.91 | 0.23 | 1.14 |
| Total Points: | 52.19 | 58.65 | -6.46 |