| 9/2/2021 | Bethel KS (9-2,9-1) | 24 | at | McPherson | 0 | |||
| 9/11/2021 | McPherson | 42 | at | Tabor (3-8,2-8) | 9 | |||
| 9/18/2021 | Ottawa (5-6,4-6) | 14 | at | McPherson | 33 | |||
| 10/2/2021 | Southwestern (9-2,9-1) | 45 | at | McPherson | 34 | |||
| 10/9/2021 | McPherson | 24 | at | Friends (1-9,1-9) | 17 | |||
| 10/16/2021 | McPherson | 17 | at | Kansas Wesleyan (10-2,9-1) | 45 | |||
| 10/23/2021 | Bethany KS (0-10,0-10) | 0 | at | McPherson | 62 | |||
| 10/30/2021 | McPherson | 28 | at | St Mary KS (3-7,3-7) | 26 | |||
| 11/6/2021 | McPherson | 17 | at | Avila (7-3,7-3) | 33 | |||
| 11/13/2021 | Sterling (6-6,5-5) | 28 | at | McPherson | 48 |
| vs McPherson | vs Other Opponents | McPherson compared to OOs | |
| Record: | 4-6 | 49-49 | |
| Points Scored: | 24.10 | 29.16 | 5.06 |
| Points Allowed: | 30.50 | 28.90 | 1.60 |
| Margin: | -6.40 | 0.26 | 6.66 |
| Total Points: | 54.60 | 58.06 | -3.46 |