| 8/28/2021 | Sterling | 38 | at | Midland U. | 36 | | | @ GPAC |
| Ottawa | 42 | at | Panhandle State | 7 | | | @ Soon |
| Arkansas Baptist | 14 | at | Tabor | 29 | | | None (Unk?) |
| 9/2/2021 | Bethel KS | 24 | at | McPherson | 0 | | | |
| 9/4/2021 | Tabor | 24 | at | Avila | 65 | | | |
| Kansas Wesleyan | 65 | at | Friends | 7 | | | |
| Ottawa | 13 | at | Southwestern | 41 | | | |
| St Mary KS | 10 | at | Sterling | 49 | | | |
| 9/11/2021 | Southwestern | 35 | at | Bethany KS | 9 | | | |
| Friends | 3 | at | Bethel KS | 59 | | | |
| Sterling | 7 | at | Kansas Wesleyan | 31 | | | |
| Avila | 38 | at | Ottawa | 14 | | | |
| McPherson | 42 | at | Tabor | 9 | | | |
| 9/18/2021 | Bethany KS | 15 | at | Avila | 46 | | | |
| Kansas Wesleyan | 31 | at | Bethel KS | 24 | | | |
| Tabor | 28 | at | Friends | 21 | | | |
| Ottawa | 14 | at | McPherson | 33 | | | |
| St Mary KS | 0 | at | Southwestern | 44 | | | |
| 9/25/2021 | Southwestern | 34 | at | Avila | 26 | | | |
| Kansas Wesleyan | 54 | at | Bethany KS | 0 | | | |
| Bethel KS | 40 | at | Ottawa | 17 | | | |
| Friends | 7 | at | St Mary KS | 55 | | | |
| Sterling | 45 | at | Tabor | 18 | | | |
| 10/2/2021 | Bethany KS | 6 | at | Bethel KS | 69 | | | |
| St Mary KS | 7 | at | Kansas Wesleyan | 49 | | | |
| Southwestern | 45 | at | McPherson | 34 | | | |
| Tabor | 22 | at | Ottawa | 45 | | | |
| Avila | 34 | at | Sterling | 31 | | | |
| 10/9/2021 | Kansas Wesleyan | 30 | at | Avila | 20 | | | |
| Sterling | 50 | at | Bethany KS | 7 | | | |
| McPherson | 24 | at | Friends | 17 | | | |
| Bethel KS | 37 | at | Southwestern | 31 | 2OT | | |
| Ottawa | 37 | at | St Mary KS | 14 | | | |
| 10/16/2021 | St Mary KS | 38 | at | Bethany KS | 6 | | | |
| Avila | 20 | at | Bethel KS | 54 | | | |
| McPherson | 17 | at | Kansas Wesleyan | 45 | | | |
| Friends | 14 | at | Sterling | 42 | | | |
| Southwestern | 42 | at | Tabor | 21 | | | |
| 10/23/2021 | Bethany KS | 0 | at | McPherson | 62 | | | |
| Friends | 14 | at | Ottawa | 28 | | | |
| Avila | 39 | at | St Mary KS | 31 | | | |
| Bethel KS | 42 | at | Sterling | 21 | | | |
| Kansas Wesleyan | 48 | at | Tabor | 21 | | | |
| 10/30/2021 | Tabor | 21 | at | Bethel KS | 49 | | | |
| Bethany KS | 13 | at | Friends | 35 | | | |
| Ottawa | 21 | at | Kansas Wesleyan | 35 | | | |
| Sterling | 14 | at | Southwestern | 42 | | | |
| McPherson | 28 | at | St Mary KS | 26 | | | |
| 11/6/2021 | McPherson | 17 | at | Avila | 33 | | | |
| Tabor | 52 | at | Bethany KS | 27 | | | |
| Arkansas Baptist | 6 | at | Kansas Wesleyan | 81 | | | None (Unk?) |
| Friends | 17 | at | Southwestern | 38 | | | |
| Bethel KS | 54 | at | St Mary KS | 21 | | | |
| Ottawa | 6 | at | Sterling | 21 | | | |
| 11/13/2021 | Avila | 37 | at | Friends | 0 | | | |
| Southwestern | 42 | at | Kansas Wesleyan | 24 | | | |
| Sterling | 28 | at | McPherson | 48 | | | |
| Bethany KS | 17 | at | Ottawa | 55 | | | |
| St Mary KS | 14 | at | Tabor | 7 | | | |
| Bethel KS | 9 | at | West Texas A&M | 52 | | | @ LSC (D2) |
| 11/20/2021 | Kansas Wesleyan | | at | Indiana Wesleyan | | | Forfeit | @ MSFA |
| Southwestern | 17 | at | Marian IN | 21 | | | @ MSFA |
| Sterling | 14 | at | Southwestern Assemblies of God | 31 | | | @ Soon |
| 11/27/2021 | Kansas Wesleyan | 21 | at | Morningside | 58 | | | @ GPAC |