| 9/4/2021 | Ottawa (5-6,4-6) | 13 | at | Southwestern | 41 | |||
| 9/11/2021 | Southwestern | 35 | at | Bethany KS (0-10,0-10) | 9 | |||
| 9/18/2021 | St Mary KS (3-7,3-7) | 0 | at | Southwestern | 44 | |||
| 9/25/2021 | Southwestern | 34 | at | Avila (7-3,7-3) | 26 | |||
| 10/2/2021 | Southwestern | 45 | at | McPherson (6-4,6-4) | 34 | |||
| 10/9/2021 | Bethel KS (9-2,9-1) | 37 | at | Southwestern | 31 | 2OT | ||
| 10/16/2021 | Southwestern | 42 | at | Tabor (3-8,2-8) | 21 | |||
| 10/30/2021 | Sterling (6-6,5-5) | 14 | at | Southwestern | 42 | |||
| 11/6/2021 | Friends (1-9,1-9) | 17 | at | Southwestern | 38 | |||
| 11/13/2021 | Southwestern | 42 | at | Kansas Wesleyan (10-2,9-1) | 24 | |||
| 11/20/2021 | Southwestern | 17 | at | Marian IN (9-3) | 21 | at MSFA |
| vs Southwestern | vs Other Opponents | Southwestern compared to OOs | |
| Record: | 2-9 | 57-51 | |
| Points Scored: | 19.64 | 29.68 | 10.04 |
| Points Allowed: | 37.36 | 27.08 | 10.28 |
| Margin: | -17.72 | 2.60 | 20.32 |
| Total Points: | 57.00 | 56.76 | 0.24 |