| 9/4/2021 | Lyon (2-8,2-7) | 10 | at | Ottawa AZ | 76 | |||
| 9/11/2021 | Ottawa AZ | 42 | at | Southwestern Assemblies of God (9-3,6-3) | 28 | |||
| 9/18/2021 | Texas Wesleyan (7-3,7-2) | 31 | at | Ottawa AZ | 45 | |||
| 9/25/2021 | Ottawa AZ | 49 | at | Louisiana College (4-7,4-5) | 19 | |||
| 10/2/2021 | Arizona Christian (8-2,7-2) | 34 | at | Ottawa AZ | 52 | |||
| 10/9/2021 | Ottawa AZ | 48 | at | Texas College (0-11,0-9) | 6 | |||
| 10/23/2021 | Langston (7-3,6-3) | 44 | at | Ottawa AZ | 41 | |||
| 11/6/2021 | Ottawa AZ | 61 | at | Wayland Baptist (2-8,2-7) | 30 | |||
| 11/13/2021 | Panhandle State (4-7,3-6) | 35 | at | Ottawa AZ | 52 | |||
| 11/20/2021 | Ottawa AZ | 38 | at | Morningside (14-0) | 63 | at GPAC |
| vs Ottawa AZ | vs Other Opponents | Ottawa AZ compared to OOs | |
| Record: | 2-8 | 55-44 | |
| Points Scored: | 30.00 | 33.77 | 3.77 |
| Points Allowed: | 50.40 | 30.19 | 20.21 |
| Margin: | -20.40 | 3.58 | 23.98 |
| Total Points: | 80.40 | 63.96 | 16.44 |