| 8/28/2021 | Lincoln CA | 9 | at | Arizona Christian | 33 | | | None (Unk?) |
| North American U | 42 | at | Louisiana College | 41 | | | None (Unk?) |
| Lyon | 14 | at | Missouri Baptist | 31 | | | @ MSFA |
| Ottawa | 42 | at | Panhandle State | 7 | | | KCAC |
| 9/2/2021 | Texas College | 0 | at | West Texas A&M | 73 | | | @ LSC (D2) |
| 9/4/2021 | Wayland Baptist | 0 | at | Hardin-Simmons | 49 | | | @ ASWC (D3) |
| Southwestern Assemblies of God | 20 | at | Louisiana College | 13 | | | |
| Langston | 10 | at | Panhandle State | 7 | | | |
| Lyon | 10 | at | Ottawa AZ | 76 | | | |
| Arizona Christian | 28 | at | Texas Wesleyan | 35 | | | |
| 9/11/2021 | Louisiana College | 7 | at | Abilene Christian | 62 | | | @ WAC (1AA) |
| Texas College | 6 | at | Langston | 44 | | | |
| Wayland Baptist | 31 | at | Lyon | 7 | | | |
| Texas Wesleyan | 49 | at | Panhandle State | 20 | | | |
| Ottawa AZ | 42 | at | Southwestern Assemblies of God | 28 | | | |
| 9/18/2021 | Louisiana College | 22 | at | Arizona Christian | 35 | | | |
| Texas Wesleyan | 31 | at | Ottawa AZ | 45 | | | |
| Millsaps | 21 | at | Southwestern Assemblies of God | 38 | | | SAA (D3) |
| Panhandle State | 68 | at | Texas College | 0 | | | |
| Langston | 50 | at | Wayland Baptist | 0 | | | |
| 9/25/2021 | Southwestern Assemblies of God | 45 | at | Arizona Christian | 52 | | | |
| Arkansas Baptist | 6 | at | Langston | 85 | | | None (Unk?) |
| Ottawa AZ | 49 | at | Louisiana College | 19 | | | |
| Lyon | 6 | at | Panhandle State | 35 | | | |
| Wayland Baptist | 38 | at | Texas College | 18 | | | |
| 10/2/2021 | Texas College | 0 | at | Lane | 71 | | | @ SIAC (D2) |
| Panhandle State | 35 | at | Louisiana College | 41 | | | |
| Langston | 30 | at | Lyon | 0 | | | |
| Arizona Christian | 34 | at | Ottawa AZ | 52 | | | |
| Arkansas Baptist | 6 | at | Southwestern Assemblies of God | 50 | | | None (Unk?) |
| Wayland Baptist | 7 | at | Texas Wesleyan | 63 | | | |
| 10/9/2021 | Arizona Christian | 55 | at | Lyon | 21 | | | |
| Texas Wesleyan | 38 | at | Southwestern Assemblies of God | 33 | | | |
| Ottawa AZ | 48 | at | Texas College | 6 | | | |
| Panhandle State | 20 | at | Wayland Baptist | 13 | | | |
| 10/16/2021 | Texas Wesleyan | 31 | at | Langston | 42 | | | |
| Southwestern Assemblies of God | 48 | at | Panhandle State | 6 | | | |
| Lyon | 33 | at | Texas College | 32 | | | |
| Louisiana College | 27 | at | Wayland Baptist | 24 | | | |
| 10/23/2021 | Texas College | 16 | at | Arizona Christian | 64 | | | |
| Arkansas Baptist | 18 | at | Panhandle State | 52 | | | None (Unk?) |
| Langston | 44 | at | Ottawa AZ | 41 | | | |
| Lyon | 21 | at | Southwestern Assemblies of God | 38 | | | |
| Louisiana College | 39 | at | Texas Wesleyan | 56 | | | |
| 10/30/2021 | Langston | 24 | at | Louisiana College | 31 | | | |
| Arizona Christian | 42 | at | Panhandle State | 35 | | | |
| Wayland Baptist | 29 | at | Southwestern Assemblies of God | 54 | | | |
| Texas College | 18 | at | Texas Wesleyan | 69 | | | |
| 11/6/2021 | Texas Wesleyan | 3 | at | Central Arkansas | 63 | | | @ WAC (1AA) |
| Arizona Christian | 40 | at | Langston | 37 | OT | | |
| Louisiana College | 33 | at | Lyon | 35 | | | |
| Southwestern Assemblies of God | 63 | at | Texas College | 0 | | | |
| Ottawa AZ | 61 | at | Wayland Baptist | 30 | | | |
| 11/13/2021 | Wayland Baptist | 16 | at | Arizona Christian | 54 | | | |
| Southwestern Assemblies of God | 41 | at | Langston | 24 | | | |
| Texas College | 12 | at | Louisiana College | 77 | | | |
| Texas Wesleyan | 48 | vs | Lyon | 13 | | | |
| Panhandle State | 35 | at | Ottawa AZ | 52 | | | |
| 11/20/2021 | Ottawa AZ | 38 | at | Morningside | 63 | | | @ GPAC |
| Sterling | 14 | at | Southwestern Assemblies of God | 31 | | | KCAC |