| 9/4/2021 | Doane | 17 | at | Briar Cliff (3-8,3-7) | 3 | |||
| 9/11/2021 | Morningside (14-0,11-0) | 56 | at | Doane | 14 | |||
| 9/18/2021 | Doane | 0 | at | Northwestern IA (12-2,9-2) | 38 | |||
| 9/25/2021 | Dordt (7-3,7-3) | 27 | at | Doane | 7 | |||
| 10/2/2021 | Jamestown (2-9,2-8) | 20 | at | Doane | 44 | |||
| 10/9/2021 | Doane | 13 | at | Dakota Wesleyan (4-7,4-6) | 17 | |||
| 10/16/2021 | Hastings (2-8,2-8) | 0 | at | Doane | 44 | |||
| 10/23/2021 | Mount Marty (0-10,0-10) | 7 | at | Doane | 28 | |||
| 10/30/2021 | Doane | 24 | at | Midland U. (6-5,6-4) | 13 | |||
| 11/6/2021 | Doane | 13 | at | Concordia NE (7-3,7-3) | 20 |
| vs Doane | vs Other Opponents | Doane compared to OOs | |
| Record: | 5-5 | 52-50 | |
| Points Scored: | 20.10 | 29.36 | 9.26 |
| Points Allowed: | 20.40 | 28.39 | -7.99 |
| Margin: | -0.30 | 0.97 | 1.27 |
| Total Points: | 40.50 | 57.75 | -17.25 |