| 8/28/2021 | Sterling (6-6) | 38 | at | Midland U. | 36 | KCAC | ||
| 9/4/2021 | Midland U. | 25 | at | Dordt (7-3,7-3) | 24 | |||
| 9/11/2021 | Northwestern IA (12-2,9-2) | 35 | at | Midland U. | 29 | OT | ||
| 9/18/2021 | Dakota Wesleyan (4-7,4-6) | 14 | at | Midland U. | 27 | |||
| 9/25/2021 | Midland U. | 33 | at | Jamestown (2-9,2-8) | 22 | |||
| 10/2/2021 | Midland U. | 14 | at | Morningside (14-0,11-0) | 59 | |||
| 10/9/2021 | Briar Cliff (3-8,3-7) | 7 | at | Midland U. | 59 | |||
| 10/23/2021 | Midland U. | 7 | at | Concordia NE (7-3,7-3) | 21 | |||
| 10/30/2021 | Doane (5-5,5-5) | 24 | at | Midland U. | 13 | |||
| 11/6/2021 | Midland U. | 35 | at | Hastings (2-8,2-8) | 17 | |||
| 11/13/2021 | Mount Marty (0-10,0-10) | 14 | at | Midland U. | 31 |
| vs Midland U. | vs Other Opponents | Midland U. compared to OOs | |
| Record: | 5-6 | 57-55 | |
| Points Scored: | 25.00 | 28.36 | 3.36 |
| Points Allowed: | 28.09 | 27.11 | 0.98 |
| Margin: | -3.09 | 1.25 | 4.34 |
| Total Points: | 53.09 | 55.47 | -2.38 |