| 8/26/2021 | Jamestown | 7 | at | Valley City State (8-2) | 24 | at NSAA | ||
| 9/11/2021 | Mount Marty (0-10,0-10) | 6 | at | Jamestown | 35 | |||
| 9/18/2021 | Jamestown | 32 | at | Hastings (2-8,2-8) | 28 | |||
| 9/25/2021 | Midland U. (6-5,6-4) | 33 | at | Jamestown | 22 | |||
| 10/2/2021 | Jamestown | 20 | at | Doane (5-5,5-5) | 44 | |||
| 10/9/2021 | Concordia NE (7-3,7-3) | 24 | at | Jamestown | 17 | |||
| 10/16/2021 | Northwestern IA (12-2,9-2) | 63 | at | Jamestown | 7 | |||
| 10/23/2021 | Briar Cliff (3-8,3-7) | 41 | at | Jamestown | 38 | |||
| 10/30/2021 | Jamestown | 7 | at | Morningside (14-0,11-0) | 70 | |||
| 11/6/2021 | Jamestown | 25 | at | Dakota Wesleyan (4-7,4-6) | 31 | |||
| 11/13/2021 | Dordt (7-3,7-3) | 77 | at | Jamestown | 6 |
| vs Jamestown | vs Other Opponents | Jamestown compared to OOs | |
| Record: | 9-2 | 59-51 | |
| Points Scored: | 40.09 | 27.35 | -12.74 |
| Points Allowed: | 19.64 | 25.21 | -5.57 |
| Margin: | 20.45 | 2.14 | -18.31 |
| Total Points: | 59.73 | 52.56 | 7.17 |