| 9/4/2021 | Thomas More (5-5,5-5) | 45 | at | Bluefield | 33 | |||
| 9/11/2021 | Bluefield | 46 | at | Emory & Henry (6-4) | 45 | at D2Ind | ||
| 9/18/2021 | Bluefield | 20 | at | Pikeville (4-5,4-5) | 52 | |||
| 9/25/2021 | Georgetown KY (8-2,8-2) | 61 | at | Bluefield | 19 | |||
| 10/2/2021 | Faulkner (7-2,7-2) | 52 | at | Bluefield | 42 | |||
| 10/9/2021 | Bluefield | 35 | at | Reinhardt (9-3,9-2) | 49 | |||
| 10/16/2021 | Bluefield | 51 | at | Warner U. (3-8,3-7) | 36 | |||
| 10/23/2021 | St Andrews (1-9,1-8) | 64 | at | Bluefield | 79 | |||
| 10/30/2021 | Bluefield | 44 | at | Kentucky Christian (3-7,3-7) | 23 | |||
| 11/6/2021 | Bluefield | 30 | at | Point (2-9,2-7) | 7 | |||
| 11/13/2021 | Union KY (2-7,2-7) | 21 | at | Bluefield | 29 |
| vs Bluefield | vs Other Opponents | Bluefield compared to OOs | |
| Record: | 5-6 | 45-55 | |
| Points Scored: | 41.36 | 25.83 | -15.53 |
| Points Allowed: | 38.91 | 28.00 | 10.91 |
| Margin: | 2.45 | -2.17 | -4.62 |
| Total Points: | 80.27 | 53.83 | 26.44 |