| 9/3/2020 | South Alabama (4-7) | 32 | at | Southern Miss | 21 | SBC | ||
| 9/19/2020 | Louisiana Tech (5-5,4-2) | 31 | at | Southern Miss | 30 | |||
| 9/26/2020 | Tulane (6-6) | 66 | at | Southern Miss | 24 | AAC | ||
| 10/3/2020 | Southern Miss | 41 | at | North Texas (4-6,3-4) | 31 | |||
| 10/17/2020 | Southern Miss | at | UTEP (3-5,0-4) | PPD | ||||
| 10/24/2020 | Southern Miss | 35 | at | Liberty (10-1) | 56 | at Ind | ||
| 10/31/2020 | Rice (2-3,2-3) | 30 | at | Southern Miss | 6 | |||
| 11/7/2020 | North Alabama (0-4) | 13 | at | Southern Miss | 24 | BigS (1AA) | ||
| 11/14/2020 | Southern Miss | 7 | at | Western Kentucky (5-7,4-3) | 10 | |||
| 11/21/2020 | Texas-San Antonio (7-5,5-2) | 23 | at | Southern Miss | 20 | |||
| 11/27/2020 | Southern Miss | at | UAB (6-3,4-1) | CCD | ||||
| 12/4/2020 | Southern Miss | at | UTEP (3-5,0-4) | CCD | ||||
| 12/10/2020 | Florida Atlantic (5-4,4-2) | 31 | at | Southern Miss | 45 |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 7-3 | 53-58 | |
| Points Scored: | 32.30 | 25.87 | -6.43 |
| Points Allowed: | 25.30 | 27.74 | -2.44 |
| Margin: | 7.00 | -1.87 | -8.87 |
| Total Points: | 57.60 | 53.61 | 3.99 |