| 9/26/2020 | UCF (6-4,5-3) | 51 | at | East Carolina | 28 | |||
| 10/3/2020 | East Carolina | 29 | at | Georgia State (6-4) | 49 | at SBC | ||
| 10/10/2020 | East Carolina | 44 | at | South Florida (1-8,0-7) | 24 | |||
| 10/17/2020 | Navy (3-7,3-4) | 27 | at | East Carolina | 23 | |||
| 10/30/2020 | East Carolina | 30 | at | Tulsa (6-3,6-1) | 34 | |||
| 11/7/2020 | Tulane (6-6,3-5) | 38 | at | East Carolina | 21 | |||
| 11/13/2020 | East Carolina | 17 | at | Cincinnati (9-1,7-0) | 55 | |||
| 11/21/2020 | East Carolina | 28 | at | Temple (1-6,1-6) | 23 | |||
| 11/28/2020 | SMU (7-3,4-3) | 38 | at | East Carolina | 52 |
| vs East Carolina | vs Other Opponents | East Carolina compared to OOs | |
| Record: | 6-3 | 39-39 | |
| Points Scored: | 37.67 | 30.38 | -7.29 |
| Points Allowed: | 30.22 | 29.58 | 0.64 |
| Margin: | 7.45 | 0.80 | -6.65 |
| Total Points: | 67.89 | 59.96 | 7.93 |