| 9/19/2020 | Austin Peay (0-3) | 20 | at | Cincinnati | 55 | OVC (1AA) | ||
| 9/26/2020 | Army (9-3) | 10 | at | Cincinnati | 24 | Ind | ||
| 10/3/2020 | South Florida (1-8,0-7) | 7 | at | Cincinnati | 28 | |||
| 10/17/2020 | Cincinnati | at | Tulsa (6-3,6-1) | PPD | ||||
| 10/24/2020 | Cincinnati | 42 | at | SMU (7-3,4-3) | 13 | |||
| 10/31/2020 | Memphis (8-3,5-3) | 10 | at | Cincinnati | 49 | |||
| 11/7/2020 | Houston (3-5,3-3) | 10 | at | Cincinnati | 38 | |||
| 11/13/2020 | East Carolina (3-6,3-5) | 17 | at | Cincinnati | 55 | |||
| 11/21/2020 | Cincinnati | 36 | at | UCF (6-4,5-3) | 33 | |||
| 11/28/2020 | Cincinnati | at | Temple (1-6,1-6) | CCD | ||||
| 12/12/2020 | Cincinnati | at | Tulsa (6-3,6-1) | CCD | ||||
| 12/19/2020 | Tulsa (6-3,6-1) | 24 | at | Cincinnati | 27 | AAC Championship | ||
| 1/1/2021 | Georgia (8-2) | 24 | vs | Cincinnati | 21 | Peach Bowl | SEC |
| vs Cincinnati | vs Other Opponents | Cincinnati compared to OOs | |
| Record: | 1-9 | 63-41 | |
| Points Scored: | 16.80 | 31.47 | 14.67 |
| Points Allowed: | 37.50 | 27.70 | 9.80 |
| Margin: | -20.70 | 3.77 | 24.47 |
| Total Points: | 54.30 | 59.17 | -4.87 |