| 10/8/2020 | Tulane (6-6,3-5) | 31 | at | Houston | 49 | |||
| 10/16/2020 | BYU (11-1) | 43 | at | Houston | 26 | Ind | ||
| 10/24/2020 | Houston | 37 | at | Navy (3-7,3-4) | 21 | |||
| 10/31/2020 | UCF (6-4,5-3) | 44 | at | Houston | 21 | |||
| 11/7/2020 | Houston | 10 | at | Cincinnati (9-1,7-0) | 38 | |||
| 11/14/2020 | South Florida (1-8,0-7) | 21 | at | Houston | 56 | |||
| 11/21/2020 | Houston | at | SMU (7-3,4-3) | PPD | ||||
| 11/28/2020 | Tulsa (6-3,6-1) | at | Houston | CCD | ||||
| 12/5/2020 | Houston | at | SMU (7-3,4-3) | PPD | ||||
| 12/12/2020 | Houston | 27 | at | Memphis (8-3,5-3) | 30 | |||
| 12/24/2020 | Hawaii (5-4) | 28 | vs | Houston | 14 | New Mexico Bowl | MW |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 5-3 | 64-40 | |
| Points Scored: | 32.00 | 33.11 | 1.11 |
| Points Allowed: | 30.00 | 27.02 | 2.98 |
| Margin: | 2.00 | 6.09 | 4.09 |
| Total Points: | 62.00 | 60.13 | 1.87 |