| 8/29/2020 | Central Arkansas | 24 | vs | Austin Peay | 17 | Montgomery, AL | vs SLC | |
| 9/5/2020 | Eastern Kentucky | 0 | at | Marshall | 59 | @ CUSA (1A) | ||
| 9/12/2020 | Austin Peay | 0 | at | Pittsburgh | 55 | @ ACC (1A) | ||
| Eastern Kentucky | 10 | at | West Virginia | 56 | @ B12 (1A) | |||
| 9/19/2020 | Austin Peay | 20 | at | Cincinnati | 55 | @ AAC (1A) | ||
| 9/26/2020 | Eastern Kentucky | 37 | at | The Citadel | 14 | @ SoCon | ||
| 10/3/2020 | Houston Baptist | 33 | at | Eastern Kentucky | 30 | SLC | ||
| Jacksonville State | 24 | at | Florida State | 41 | @ ACC (1A) | |||
| 10/10/2020 | Mercer | 28 | at | Jacksonville State | 34 | SoCon | ||
| 10/17/2020 | Jacksonville State | 24 | at | North Alabama | 17 | @ BigS | ||
| Eastern Kentucky | 29 | at | Troy | 31 | @ SBC (1A) | |||
| 10/23/2020 | Jacksonville State | 19 | at | Florida Intl | 10 | @ CUSA (1A) | ||
| 10/24/2020 | Central Arkansas | 28 | at | Eastern Kentucky | 31 | SLC | ||
| Jacksonville State | 19 | at | Florida Intl | 10 | @ CUSA (1A) | |||
| 10/30/2020 | SE Missouri State | 17 | at | Southern Illinois | 20 | @ MVC | ||
| 11/7/2020 | Stephen F. Austin | 24 | at | Eastern Kentucky | 6 | SLC | ||
| 11/14/2020 | Eastern Kentucky | 25 | at | Central Arkansas | 37 | @ SLC | ||
| 11/21/2020 | Western Carolina | 17 | at | Eastern Kentucky | 49 | SoCon |