| 8/30/2018 | Quincy | 0 | at | Indiana State (7-4) | 49 | at MVC | ||
| 9/8/2018 | Kentucky Wesleyan (3-7) | 24 | at | Quincy | 31 | GMAC | ||
| 9/15/2018 | St Francis IL (4-7) | 41 | at | Quincy | 26 | MSFA (NAIA) | ||
| 9/22/2018 | Davenport (6-5) | 26 | at | Quincy | 10 | GLIAC | ||
| 9/29/2018 | McKendree (6-5,4-3) | 48 | at | Quincy | 14 | |||
| 10/6/2018 | Quincy | 14 | at | Lincoln MO (3-8,2-5) | 13 | |||
| 10/13/2018 | Indianapolis (10-2,7-0) | 35 | at | Quincy | 7 | |||
| 10/20/2018 | Missouri S&T (10-2,6-1) | 20 | at | Quincy | 13 | |||
| 10/27/2018 | Quincy | 7 | at | Truman State (6-5,5-2) | 41 | |||
| 11/3/2018 | Quincy | 23 | at | William Jewell (1-9,1-6) | 17 | |||
| 11/10/2018 | Southwest Baptist (0-10,0-7) | 21 | at | Quincy | 24 |
| vs Quincy | vs Other Opponents | Quincy compared to OOs | |
| Record: | 7-4 | 49-60 | |
| Points Scored: | 30.45 | 25.29 | -5.16 |
| Points Allowed: | 15.36 | 30.03 | -14.67 |
| Margin: | 15.09 | -4.74 | -19.83 |
| Total Points: | 45.81 | 55.32 | -9.51 |