| 9/1/2018 | Northern Michigan (3-8) | 28 | at | McKendree | 34 | GLIAC | ||
| 9/8/2018 | McKendree | 34 | at | Kentucky State (0-10) | 17 | at SIAC | ||
| 9/15/2018 | Bowie State (10-3) | 47 | at | McKendree | 41 | CIAA | ||
| 9/22/2018 | McKendree | 45 | at | Chowan (6-4) | 55 | at CIAA | ||
| 9/29/2018 | McKendree | 48 | at | Quincy (4-7,3-4) | 14 | |||
| 10/6/2018 | Truman State (6-5,5-2) | 45 | at | McKendree | 38 | |||
| 10/13/2018 | McKendree | 26 | at | Southwest Baptist (0-10,0-7) | 23 | |||
| 10/20/2018 | McKendree | 10 | at | Indianapolis (10-2,7-0) | 48 | |||
| 10/27/2018 | William Jewell (1-9,1-6) | 31 | at | McKendree | 47 | |||
| 11/3/2018 | Missouri S&T (10-2,6-1) | 49 | at | McKendree | 20 | |||
| 11/10/2018 | McKendree | 50 | at | Lincoln MO (3-8,2-5) | 32 |
| vs McKendree | vs Other Opponents | McKendree compared to OOs | |
| Record: | 5-6 | 48-62 | |
| Points Scored: | 35.36 | 24.16 | -11.20 |
| Points Allowed: | 35.73 | 28.09 | 7.64 |
| Margin: | -0.37 | -3.93 | -3.56 |
| Total Points: | 71.09 | 52.25 | 18.84 |