| 9/3/2018 | Virginia Tech | 24 | at | Florida State (5-7,3-5) | 3 | |||
| 9/8/2018 | William & Mary (4-6) | 17 | at | Virginia Tech | 62 | CAAF (1AA) | ||
| 9/15/2018 | East Carolina (3-9) | vs | Virginia Tech | CCD | AAC | |||
| 9/22/2018 | Virginia Tech | 35 | at | Old Dominion (4-8) | 49 | at CUSA | ||
| 9/29/2018 | Virginia Tech | 31 | at | Duke (8-5,3-5) | 14 | |||
| 10/6/2018 | Notre Dame (12-1) | 45 | at | Virginia Tech | 23 | ND | ||
| 10/13/2018 | Virginia Tech | 22 | at | North Carolina (2-9,1-7) | 19 | |||
| 10/25/2018 | Georgia Tech (7-6,5-3) | 49 | at | Virginia Tech | 28 | |||
| 11/3/2018 | Boston College (7-5,4-4) | 31 | at | Virginia Tech | 21 | |||
| 11/10/2018 | Virginia Tech | 22 | at | Pittsburgh (7-7,6-3) | 52 | |||
| 11/17/2018 | Miami-Florida (7-6,4-4) | 38 | at | Virginia Tech | 14 | |||
| 11/23/2018 | Virginia (8-5,4-4) | 31 | at | Virginia Tech | 34 | |||
| 12/1/2018 | Marshall (9-4) | 20 | at | Virginia Tech | 41 | CUSA | ||
| 12/31/2018 | Cincinnati (11-2) | 35 | vs | Virginia Tech | 31 | MILITARY BOWL PRESENTED BY NORTHROP GRUMMAN - Annapolis MD | AAC |
| vs Virginia Tech | vs Other Opponents | Virginia Tech compared to OOs | |
| Record: | 7-6 | 87-74 | |
| Points Scored: | 31.00 | 27.80 | -3.20 |
| Points Allowed: | 29.85 | 26.11 | 3.74 |
| Margin: | 1.15 | 1.69 | 0.54 |
| Total Points: | 60.85 | 53.91 | 6.94 |