| 9/1/2018 | Appalachian State | 38 | at | Penn State (9-4) | 45 | OT | at B10 | |
| 9/8/2018 | Appalachian State | 45 | at | UNC-Charlotte (5-7) | 9 | at CUSA | ||
| 9/15/2018 | Southern Miss (6-5) | at | Appalachian State | PPD | CUSA | |||
| 9/22/2018 | Gardner-Webb (3-8) | 7 | at | Appalachian State | 72 | BigS (1AA) | ||
| 9/29/2018 | South Alabama (3-9,2-6) | 7 | at | Appalachian State | 52 | |||
| 10/9/2018 | Appalachian State | 35 | at | Arkansas State (8-5,5-3) | 9 | |||
| 10/20/2018 | UL Lafayette (7-7,5-4) | 17 | at | Appalachian State | 27 | |||
| 10/25/2018 | Appalachian State | 14 | at | Georgia Southern (10-3,6-2) | 34 | |||
| 11/3/2018 | Appalachian State | 23 | at | Coastal Carolina (5-7,2-6) | 7 | |||
| 11/10/2018 | Appalachian State | 38 | at | Texas State (3-9,1-7) | 7 | |||
| 11/17/2018 | Georgia State (2-10,1-7) | 17 | at | Appalachian State | 45 | |||
| 11/24/2018 | Troy (10-3,7-1) | 10 | at | Appalachian State | 21 | |||
| 12/1/2018 | UL Lafayette (7-7,5-4) | 19 | at | Appalachian State | 30 | Sun Belt Championship | ||
| 12/15/2018 | Middle Tenn State (8-6) | 13 | vs | Appalachian State | 45 | R+L CARRIERS NEW ORLEANS BOWL | CUSA |
| vs Appalachian State | vs Other Opponents | Appalachian State compared to OOs | |
| Record: | 2-11 | 84-77 | |
| Points Scored: | 15.46 | 28.67 | 13.21 |
| Points Allowed: | 37.31 | 28.64 | 8.67 |
| Margin: | -21.85 | 0.03 | 21.88 |
| Total Points: | 52.77 | 57.31 | -4.54 |