| 8/31/2018 | Utah State (11-2) | 31 | at | Michigan State | 38 | MW | ||
| 9/8/2018 | Michigan State | 13 | at | Arizona State (7-6) | 16 | at P12 | ||
| 9/22/2018 | Michigan State | 35 | at | Indiana (5-7,2-7) | 21 | |||
| 9/29/2018 | Central Michigan (1-11) | 20 | at | Michigan State | 31 | MAC | ||
| 10/6/2018 | Northwestern (9-5,8-2) | 29 | at | Michigan State | 19 | |||
| 10/13/2018 | Michigan State | 21 | at | Penn State (9-4,6-3) | 17 | |||
| 10/20/2018 | Michigan (10-3,8-1) | 21 | at | Michigan State | 7 | |||
| 10/27/2018 | Purdue (6-7,5-4) | 13 | at | Michigan State | 23 | |||
| 11/3/2018 | Michigan State | 24 | at | Maryland (5-7,3-6) | 3 | |||
| 11/10/2018 | Ohio State (13-1,9-1) | 26 | at | Michigan State | 6 | |||
| 11/17/2018 | Michigan State | 6 | at | Nebraska (4-8,3-6) | 9 | |||
| 11/24/2018 | Rutgers (1-11,0-9) | 10 | at | Michigan State | 14 | |||
| 12/31/2018 | Michigan State | 6 | vs | Oregon (9-4) | 7 | REDBOX BOWL - Santa Clara CA | vs P12 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 6-7 | 84-69 | |
| Points Scored: | 17.15 | 31.52 | 14.37 |
| Points Allowed: | 18.69 | 26.75 | -8.06 |
| Margin: | -1.54 | 4.77 | 6.31 |
| Total Points: | 35.84 | 58.27 | -22.43 |