| 9/1/2018 | Middle Tenn State | 7 | at | Vanderbilt (6-7) | 35 | at SEC | ||
| 9/8/2018 | Tennessee-Martin (2-9) | 37 | at | Middle Tenn State | 61 | OVC (1AA) | ||
| 9/15/2018 | Middle Tenn State | 7 | at | Georgia (11-3) | 49 | at SEC | ||
| 9/29/2018 | Florida Atlantic (5-7,3-5) | 24 | at | Middle Tenn State | 25 | |||
| 10/5/2018 | Middle Tenn State | 34 | at | Marshall (9-4,6-2) | 24 | |||
| 10/13/2018 | Middle Tenn State | 21 | at | Florida Intl (9-4,6-2) | 24 | |||
| 10/20/2018 | UNC-Charlotte (5-7,4-4) | 13 | at | Middle Tenn State | 21 | |||
| 10/27/2018 | Middle Tenn State | 51 | at | Old Dominion (4-8,2-6) | 17 | |||
| 11/2/2018 | Western Kentucky (3-9,2-6) | 10 | at | Middle Tenn State | 29 | |||
| 11/10/2018 | Middle Tenn State | 48 | at | UTEP (1-11,1-7) | 32 | |||
| 11/17/2018 | Middle Tenn State | 23 | at | Kentucky (10-3) | 34 | at SEC | ||
| 11/24/2018 | UAB (11-3,8-1) | 3 | at | Middle Tenn State | 27 | |||
| 12/1/2018 | UAB (11-3,8-1) | 27 | at | Middle Tenn State | 25 | CUSA Championship | ||
| 12/15/2018 | Middle Tenn State | 13 | vs | Appalachian State (11-2) | 45 | R+L CARRIERS NEW ORLEANS BOWL | vs SBC |
| vs Middle Tenn State | vs Other Opponents | Middle Tenn State compared to OOs | |
| Record: | 6-8 | 91-71 | |
| Points Scored: | 26.71 | 29.67 | 2.96 |
| Points Allowed: | 28.00 | 24.49 | 3.51 |
| Margin: | -1.29 | 5.18 | 6.47 |
| Total Points: | 54.71 | 54.16 | 0.55 |