| 8/31/2017 | McKendree | 2 | at | Angelo State | 42 | GLV | ||
| Southwest Baptist | 21 | at | Eastern New Mexico | 23 | GLV | |||
| Quincy | 6 | at | Midwestern State | 53 | GLV | |||
| 9/1/2017 | Texas A&M-Commerce | 8 | at | North Alabama | 7 | @ GSC | ||
| 9/2/2017 | Tarleton State | 16 | at | Delta State | 34 | @ GSC | ||
| Western New Mexico | 20 | at | San Diego | 34 | @ Pio (1AA) | |||
| Central Washington | 34 | at | Texas A&M-Kingsville | 10 | GNWAC | |||
| Sul Ross State | 47 | at | Texas-Permian Basin | 22 | ASWC (D3) | |||
| Azusa Pacific | 24 | at | West Texas A&M | 13 | GNWAC | |||
| 9/9/2017 | Northern Michigan | 20 | at | Angelo State | 48 | GLIAC | ||
| Texas-Permian Basin | 6 | at | Lamar | 72 | @ SLC (1AA) | |||
| Texas A&M-Kingsville | 35 | at | Simon Fraser | 7 | @ GNWAC | |||
| William Jewell | 6 | at | Texas A&M-Commerce | 59 | GLV | |||
| Panhandle State | 20 | at | Tarleton State | 48 | CSFL (NAIA) | |||
| Midwestern State | at | West Florida | Cancelled WX | @ GSC | ||||
| Colorado State-Pueblo | 21 | at | West Texas A&M | 24 | RMAC | |||
| Eastern New Mexico | 37 | at | Western New Mexico | 34 | ||||
| 9/16/2017 | Tarleton State | 30 | at | Angelo State | 24 | |||
| Texas A&M-Kingsville | 13 | at | Midwestern State | 35 | ||||
| Eastern New Mexico | 22 | at | Texas A&M-Commerce | 51 | ||||
| Texas-Permian Basin | 6 | at | West Texas A&M | 17 | ||||
| Western Oregon | 58 | at | Western New Mexico | 21 | GNWAC | |||
| 9/23/2017 | Angelo State | 21 | at | Eastern New Mexico | 31 | |||
| Texas A&M-Commerce | 38 | at | Texas A&M-Kingsville | 7 | ||||
| West Texas A&M | 20 | at | Tarleton State | 30 | ||||
| Texas-Permian Basin | 41 | at | Western New Mexico | 32 | ||||
| 9/30/2017 | Texas A&M-Kingsville | 14 | at | Angelo State | 40 | |||
| Western New Mexico | 24 | at | Midwestern State | 35 | ||||
| Tarleton State | 32 | at | Texas-Permian Basin | 17 | ||||
| Eastern New Mexico | 28 | at | West Texas A&M | 14 | ||||
| 10/7/2017 | Texas-Permian Basin | 17 | at | Eastern New Mexico | 20 | |||
| Texas A&M-Commerce | 42 | at | Midwestern State | 47 | ||||
| West Texas A&M | 9 | at | Texas A&M-Kingsville | 37 | ||||
| Tarleton State | 25 | at | Western New Mexico | 38 | ||||
| 10/14/2017 | Midwestern State | 41 | at | Angelo State | 27 | |||
| Western New Mexico | 3 | at | Texas A&M-Commerce | 52 | ||||
| Eastern New Mexico | 24 | at | Tarleton State | 15 | ||||
| Texas A&M-Kingsville | 47 | at | Texas-Permian Basin | 21 | ||||
| Adams State | 14 | at | West Texas A&M | 17 | RMAC | |||
| 10/21/2017 | West Texas A&M | 3 | at | Midwestern State | 45 | |||
| Texas-Permian Basin | 42 | vs | Quincy | 7 | Miami OK | vs GLV | ||
| Angelo State | 20 | at | Texas A&M-Commerce | 34 | ||||
| Tarleton State | 41 | at | Texas A&M-Kingsville | 34 | ||||
| Fort Lewis | 17 | at | Western New Mexico | 20 | RMAC | |||
| 10/28/2017 | Western New Mexico | 7 | at | Angelo State | 44 | |||
| Texas A&M-Kingsville | 34 | at | Eastern New Mexico | 51 | ||||
| Western Oregon | 6 | at | Tarleton State | 28 | GNWAC | |||
| Midwestern State | 66 | vs | Texas-Permian Basin | 8 | Midland TX | |||
| Texas A&M-Commerce | 35 | at | West Texas A&M | 16 | ||||
| 11/2/2017 | Eastern New Mexico | 45 | at | West Liberty | 24 | @ MtnE | ||
| 11/4/2017 | West Texas A&M | 3 | at | Angelo State | 51 | |||
| Tarleton State | 42 | at | Midwestern State | 45 | OT | |||
| Texas-Permian Basin | 0 | at | Texas A&M-Commerce | 52 | ||||
| Texas A&M-Kingsville | 23 | at | Western New Mexico | 35 | ||||
| 11/11/2017 | Midwestern State | 56 | at | Eastern New Mexico | 43 | |||
| William Jewell | 34 | at | Texas A&M-Kingsville | 38 | GLV | |||
| Texas A&M-Commerce | 33 | at | Tarleton State | 21 | ||||
| Angelo State | 74 | at | Texas-Permian Basin | 24 | ||||
| Western New Mexico | 21 | at | West Texas A&M | 17 | ||||
| 11/18/2017 | Sioux Falls | 20 | at | Midwestern State | 24 | NSIC | ||
| Texas A&M-Commerce | 20 | at | Winona State | 6 | @ NSIC | |||
| 11/25/2017 | Texas A&M-Commerce | 34 | at | Central Washington | 31 | 2OT | D2 Playoff Round 2 | @ GNWAC |
| Midwestern State | 21 | at | Minnesota State-Mankato | 63 | D2 Playoff Round 2 | @ NSIC | ||
| 12/2/2017 | Washburn | 41 | vs | Angelo State | 25 | Copperas Cove TX | vs MAIAA | |
| Texas A&M-Commerce | 31 | at | Minnesota State-Mankato | 21 | D2 Playoff Quarterfinal | @ NSIC | ||
| Central Oklahoma | 38 | vs | Tarleton State | 31 | Corsicana TX | vs MAIAA | ||
| 12/9/2017 | Harding | 17 | at | Texas A&M-Commerce | 31 | D2 Playoff Semifinal | GAC | |
| 12/16/2017 | West Florida | 27 | vs | Texas A&M-Commerce | 37 | D2 Championship (Kansas City KS) | vs GSC |