| 8/31/2017 | Henderson State (6-5,6-5) | 28 | at | Harding | 20 | | | |
| 9/9/2017 | Harding | 24 | at | Southern Arkansas (7-4,7-4) | 35 | | | |
| 9/16/2017 | Southern Nazarene (4-7,4-7) | 28 | at | Harding | 27 | | | |
| 9/23/2017 | Harding | 45 | at | Oklahoma Baptist (2-9,2-9) | 14 | | | |
| 9/30/2017 | Arkansas-Monticello (5-6,5-6) | 46 | at | Harding | 56 | | | |
| 10/7/2017 | Harding | 31 | at | Ouachita (9-3,9-2) | 28 | | | |
| 10/14/2017 | Harding | 34 | at | Northwestern Oklahoma State (5-6,5-6) | 0 | | | |
| 10/21/2017 | Southwestern Oklahoma State (3-8,3-8) | 0 | at | Harding | 42 | | | |
| 10/28/2017 | Harding | 42 | at | Southeastern Oklahoma State (7-4,7-4) | 3 | | | |
| 11/4/2017 | East Central (2-9,2-9) | 13 | at | Harding | 44 | | | |
| 11/11/2017 | Harding | 24 | at | Arkansas Tech (8-4,8-3) | 17 | | | |
| 11/18/2017 | Harding | 27 | at | Indianapolis (11-1) | 24 | | | at GLV |
| 11/25/2017 | Harding | 34 | at | Ashland (11-2) | 24 | | D2 Playoff Round 2 | at GLIAC |
| 12/2/2017 | Harding | 16 | at | Ferris State (11-2) | 14 | | D2 Playoff Quarterfinal | at GLIAC |
| 12/9/2017 | Harding | 17 | at | Texas A&M-Commerce (14-1) | 31 | | D2 Playoff Semifinal | at LSC |