| 8/31/2017 | McMurry (2-8) | 0 | at | Panhandle State | 10 | ASWC (D3) | ||
| 9/9/2017 | Panhandle State | 20 | at | Tarleton State (6-6) | 48 | at LSC | ||
| 9/16/2017 | Panhandle State | 31 | at | Bacone (2-9,2-6) | 8 | |||
| 9/23/2017 | Lyon (5-6,3-5) | 21 | at | Panhandle State | 42 | |||
| 10/7/2017 | Panhandle State | 35 | at | Wayland Baptist (4-6,4-4) | 24 | |||
| 10/14/2017 | Panhandle State | 33 | at | Arizona Christian (7-3,5-3) | 28 | |||
| 10/21/2017 | Southwestern Assemblies of God (8-3,7-1) | 29 | at | Panhandle State | 21 | |||
| 10/28/2017 | Langston (10-1,8-0) | 27 | at | Panhandle State | 14 | |||
| 11/4/2017 | Panhandle State | 34 | at | Texas College (1-9,1-7) | 13 | |||
| 11/11/2017 | Texas Wesleyan (0-11,0-8) | 6 | at | Panhandle State | 65 |
| vs Panhandle State | vs Other Opponents | Panhandle State compared to OOs | |
| Record: | 3-7 | 42-55 | |
| Points Scored: | 20.40 | 25.21 | 4.81 |
| Points Allowed: | 30.50 | 30.02 | 0.48 |
| Margin: | -10.10 | -4.81 | 5.29 |
| Total Points: | 50.90 | 55.23 | -4.33 |