| 9/2/2017 | West Florida | 20 | at | Missouri S&T (7-4) | 16 | at GLV | ||
| 9/9/2017 | Midwestern State (10-1) | at | West Florida | Cancelled WX | LSC | |||
| 9/16/2017 | Chowan (4-6) | 23 | at | West Florida | 51 | CIAA | ||
| 9/23/2017 | Valdosta State (5-4,5-3) | 30 | at | West Florida | 19 | |||
| 9/30/2017 | West Florida | 23 | at | Florida Tech (5-6,3-5) | 21 | |||
| 10/6/2017 | Mississippi College (1-9,1-7) | 14 | at | West Florida | 28 | |||
| 10/14/2017 | Delta State (9-4,5-4) | 28 | at | West Florida | 25 | |||
| 10/21/2017 | West Florida | 42 | at | Shorter (0-11,0-8) | 29 | |||
| 10/28/2017 | West Florida | 18 | at | West Alabama (10-3,8-2) | 35 | |||
| 11/4/2017 | North Alabama (5-5,5-3) | 7 | at | West Florida | 30 | |||
| 11/11/2017 | West Florida | 34 | at | West Georgia (9-4,5-4) | 29 | |||
| 11/18/2017 | West Florida | 31 | at | Wingate (9-2) | 0 | at SAC | ||
| 11/25/2017 | West Florida | 17 | at | West Georgia (9-4,5-4) | 14 | D2 Playoff Round 2 | ||
| 12/2/2017 | West Florida | 28 | at | West Alabama (10-3,8-2) | 21 | D2 Playoff Quarterfinal | ||
| 12/9/2017 | West Florida | 27 | at | Indiana PA (13-1) | 17 | D2 Playoff Semifinal | at PSAC | |
| 12/16/2017 | West Florida | 27 | vs | Texas A&M-Commerce (14-1) | 37 | D2 Championship (Kansas City KS) | vs LSC |
| vs West Florida | vs Other Opponents | West Florida compared to OOs | |
| Record: | 4-11 | 115-54 | |
| Points Scored: | 21.40 | 31.81 | 10.41 |
| Points Allowed: | 28.00 | 22.95 | 5.05 |
| Margin: | -6.60 | 8.86 | 15.46 |
| Total Points: | 49.40 | 54.76 | -5.36 |